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Article

Depleting components of the THO complex causes increased telomere length by reducing the expression of the telomere-associated protein Rif1p.

PloS one - 1 Jan 2012

Yu Tai-Yuan, Wang Chen-Yi, Lin Jing-Jer

Abstract excerpt

Telomere length is regulated mostly by proteins directly associated with telomeres. However, genome-wide analysis of Saccharomyces cerevisiae mutants has revealed that deletion of Hpr1p, a component of the THO complex, also affects telomere length. The THO complex comprises four protein subunits, namely, Tho2p, Hpr1p, Mft1p, and Thp2p. These subunits interplay between transcription elongation and...

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Identifiers

PMID: 22448247
DOI: 10.1371/journal.pone.0033498
PMCID: PMC3308969

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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