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Article

Telomerase is essential to alleviate pif1-induced replication stress at telomeres.

Genetics - 1 Nov 2009

Chang Michael, Luke Brian, Kraft Claudine, Li Zhijian, Peter Matthias, Lingner Joachim, Rothstein Rodney

Abstract excerpt

Pif1, an evolutionarily conserved helicase, negatively regulates telomere length by removing telomerase from chromosome ends. Pif1 has also been implicated in DNA replication processes such as Okazaki fragment maturation and replication fork pausing. We find that overexpression of Saccharomyces cervisiae PIF1 results in dose-dependent growth inhibition. Strong overexpression causes relocalization of the DNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19704012
DOI: 10.1534/genetics.109.107631
PMCID: PMC2778976

Genes

PIF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Telomerase is essential to alleviate pif1-induced replication stress at telomeres.PMID 19704012Read ↗

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Evidence suggesting that Pif1 helicase functions in DNA replication with the Dna2 helicase/nuclease and DNA polymerase delta.Semantic proximity Read ↗

Mrc1 is required for normal progression of replication forks throughout chromatin in S. cerevisiae.Semantic proximity Read ↗

The Pif1 family helicase Pfh1 facilitates telomere replication and has an RPA-dependent role during telomere lengthening.Semantic proximity Read ↗

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