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Article

At short telomeres Tel1 directs early replication and phosphorylates Rif1.

PLoS genetics - 1 Oct 2014

Sridhar Akila, Kedziora Sylwia, Donaldson Anne D

Abstract excerpt

The replication time of Saccharomyces cerevisiae telomeres responds to TG1-3 repeat length, with telomeres of normal length replicating late during S phase and short telomeres replicating early. Here we show that Tel1 kinase, which is recruited to short telomeres, specifies their early replication, because we find a tel1Δ mutant has short telomeres that nonetheless replicate late. Consistent with a role for Tel1...

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Share to DNA Replication
Share to Intracellular Signaling Peptides and Proteins
Share to Protein Serine-Threonine Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25329891
DOI: 10.1371/journal.pgen.1004691
PMCID: PMC4199499

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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