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Article

Regulation of apoptosis by an intrinsically disordered region of Bcl-xL.

Nature chemical biology - 1 May 2018

Follis Ariele Viacava, Llambi Fabien, Kalkavan Halime, Yao Yong, Phillips Aaron H, Park Cheon-Gil, Marassi Francesca M, Green Douglas R, Kriwacki Richard W

Abstract excerpt

Intrinsically disordered regions (IDRs) of proteins often regulate function upon post-translational modification (PTM) through interactions with folded domains. An IDR linking two α-helices (α1-α2) of the antiapoptotic protein Bcl-xL experiences several PTMs that reduce antiapoptotic activity. Here, we report that PTMs within the α1-α2 IDR promote its interaction with the folded core of Bcl-xL that inhibits the...

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Identifiers

PMID: 29507390
DOI: 10.1038/s41589-018-0011-x
PMCID: PMC5899648

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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