Article

Bcl-xL dynamics and cancer-associated mutations under the lens of protein structure network and biomolecular simulations

2019-03-12

Abstract excerpt

Understanding the finely orchestrated interactions leading to or preventing programmed cell death (apoptosis) is of utmost importance in cancer research since the failure of these systems could eventually lead to the onset of the disease. In this regard, the maintenance of a delicate balance between promoters and inhibitors of mitochondrial apoptosis is crucial, as demonstrated by the interplay among the Bcl-2 fam...

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Literature Corpus work: 5a261dfe-1aa4-5e8e-88b6-7465d5b73a45
DOI: 10.1101/574699

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