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Article

Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands.

The Journal of biological chemistry - 30 Oct 2009

Lee Erinna F, Czabotar Peter E, Yang Hong, Sleebs Brad E, Lessene Guillaume, Colman Peter M, Smith Brian J, Fairlie W Douglas

Abstract excerpt

Antagonists of anti-apoptotic Bcl-2 family members hold promise as cancer therapeutics. Apoptosis is triggered when a peptide containing a BH3 motif or a small molecule BH3 peptidomimetic, such as ABT 737, binds to the relevant Bcl-2 family members. ABT-737 is an antagonist of Bcl-2, Bcl-x(L), and Bcl-w but not of Mcl-1. Here we describe new structures of mutant BH3 peptides bound to Bcl-x(L) and Mcl-1. These...

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Identifiers

PMID: 19726685
DOI: 10.1074/jbc.M109.040725
PMCID: PMC2781605

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