Article
Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis.
Nature communications - 16 Apr 2021
Wei Hudie, Qu Lingzhi, Dai Shuyan, Li Yun, Wang Haolan, Feng Yilu, Chen Xiaojuan, Jiang Longying, Guo Ming, Li Jun, Chen Zhuchu, Chen Lin, Zhang Ye, Chen Yongheng
Abstract excerpt
The tumor suppressor p53 is mutated in approximately half of all human cancers. p53 can induce apoptosis through mitochondrial membrane permeabilization by interacting with and antagonizing the anti-apoptotic proteins BCL-xL and BCL-2. However, the mechanisms by which p53 induces mitochondrial apoptosis remain elusive. Here, we report a 2.5 Å crystal structure of human p53/BCL-xL complex. In this structure, two...
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