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Article

Alterations of the interactome of Bcl-2 proteins in breast cancer at the transcriptional, mutational and structural level.

PLoS computational biology - 1 Dec 2019

Kønig Simon Mathis, Rissler Vendela, Terkelsen Thilde, Lambrughi Matteo, Papaleo Elena

Abstract excerpt

Apoptosis is an essential defensive mechanism against tumorigenesis. Proteins of the B-cell lymphoma-2 (Bcl-2) family regulate programmed cell death by the mitochondrial apoptosis pathway. In response to intracellular stress, the apoptotic balance is governed by interactions of three distinct subgroups of proteins; the activator/sensitizer BH3 (Bcl-2 homology 3)-only proteins, the pro-survival, and the...

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Identifiers

PMID: 31825969
DOI: 10.1371/journal.pcbi.1007485
PMCID: PMC6927658

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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