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Article

BclxL changes conformation upon binding to wild-type but not mutant p53 DNA binding domain.

The Journal of biological chemistry - 29 Jan 2010

Hagn Franz, Klein Christian, Demmer Oliver, Marchenko Natasha, Vaseva Angelina, Moll Ute M, Kessler Horst

Abstract excerpt

p53 can induce apoptosis through mitochondrial membrane permeabilization by interaction of its DNA binding region with the anti-apoptotic proteins BclxL and Bcl2. However, little is known about the action of p53 at the mitochondria in molecular detail. By using NMR spectroscopy and fluorescence p...

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Identifiers

PMID: 19955567
DOI: 10.1074/jbc.M109.065391
PMCID: PMC2823462

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19955567-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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