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Article

Bcl2's flexible loop domain regulates p53 binding and survival.

Molecular and cellular biology - 1 Jun 2006

Deng Xingming, Gao Fengqin, Flagg Tammy, Anderson Jessica, May W Stratford

Abstract excerpt

p53 not only functions as a transcription factor but also has a direct, apoptogenic role at the mitochondria. We have discovered that DNA damage-induced p53-Bcl2 binding is associated with decreased Bcl2-Bax interaction and increased apoptotic cell death in a mechanism regulated by Bcl2's flexible loop regulatory domain (FLD), since purified p53 protein can disrupt the Bcl2/Bax complex by directly binding to a...

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Identifiers

PMID: 16738310
DOI: 10.1128/MCB.01647-05
PMCID: PMC1489125

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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