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Article

Promiscuous and Selective: How Intrinsically Disordered BH3 Proteins Interact with Their Pro-survival Partner MCL-1.

Journal of molecular biology - 3 Aug 2018

Dahal Liza, Kwan Tristan O C, Hollins Jeffrey J, Clarke Jane

Abstract excerpt

The BCL-2 family of proteins plays a central role in regulating cell survival and apoptosis. Disordered BH3-only proteins bind promiscuously to a number of different BCL-2 proteins, with binding affinities that vary by orders of magnitude. Here we investigate the basis for these differences in affinity. We show that eight different disordered BH3 proteins all bind to their BCL-2 partner (MCL-1) very rapidly, and...

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Identifiers

PMID: 29654795
DOI: 10.1016/j.jmb.2018.04.004

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