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Structural Details of BH3 Motifs and BH3-Mediated Interactions: an Updated Perspective

24 May 2022

Abstract excerpt

Apoptosis is a mechanism of programmed cell death crucial in organism development, maintenance of tissue homeostasis, and several pathogenic processes. The B cell lymphoma 2 (BCL2) protein family lies at the core of the apoptotic process, and the delicate balance between its pro- and anti-apoptotic members ultimately decides the cell fate. BCL2 proteins can bind with each other and several other biological...

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PMID: 35685242
DOI: 10.3389/fmolb.2022.864874

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