Article
Inhibition of Pro-apoptotic BAX by a noncanonical interaction mechanism.
Molecular cell - 5 Mar 2015
Barclay Lauren A, Wales Thomas E, Garner Thomas P, Wachter Franziska, Lee Susan, Guerra Rachel M, Stewart Michelle L, Braun Craig R, Bird Gregory H, Gavathiotis Evripidis, Engen John R, Walensky Loren D
Abstract excerpt
BCL-2 is a negative regulator of apoptosis implicated in homeostatic and pathologic cell survival. The canonical anti-apoptotic mechanism involves entrapment of activated BAX by a groove on BCL-2, preventing BAX homo-oligomerization and mitochondrial membrane poration. The BCL-2 BH4 domain also confers anti-apoptotic functionality, but the mechanism is unknown. We find that a synthetic α-helical BH4 domain binds...
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