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Article

Biochemical and pharmacological profiling of the pro-survival protein Bcl-xL.

Bioorganic & medicinal chemistry letters - 1 Sept 2011

Goreshnik Inna, Brock Amanda M, Maly Dustin J

Abstract excerpt

Bcl-2 family proteins are key mediators of programmed cell death. Over-expression of anti-apoptotic Bcl-2 family members (Bcl-2, Bcl-xL, and Mcl-1) has been associated with tumor progression and chemotherapeutic resistance. Pharmacological agents that neutralize the functions of anti-apoptotic Bcl-2 family proteins have emerged as a promising new class of anti-cancer agents. Biochemical analyses have demonstrated...

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PMID: 21807512
DOI: 10.1016/j.bmcl.2011.06.134

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