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Article

Anti-apoptotic effects of IGF-I on mortality and dysmorphogenesis in tbx5-deficient zebrafish embryos.

BMC developmental biology - 5 Mar 2018

Tsai Tzu-Chun, Shih Chun-Che, Chien Hsin-Ping, Yang An-Hang, Lu Jenn-Kan, Lu Jen-Her

Abstract excerpt

BACKGROUND: Tbx5 deficiency in zebrafish causes several abnormal phenotypes of the heart and pectoral fins. It has been reported that exogenous human growth hormone can enhance expression of downstream mediators in the growth hormone and insulin-like growth factor I (IGF-I) pathway and partially restore dysmorphogenesis in tbx5 morphants. This study aimed to further evaluate the effects of IGF-I on cell apoptosis...

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Share to Embryo, Nonmammalian
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29506474
DOI: 10.1186/s12861-017-0161-1
PMCID: PMC5836385

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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