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Article

Distinct tissue-specific requirements for the zebrafish tbx5 genes during heart, retina and pectoral fin development.

Open biology - 23 Apr 2014

Pi-Roig Aina, Martin-Blanco Enrique, Minguillon Carolina

Abstract excerpt

The transcription factor Tbx5 is expressed in the developing heart, eyes and anterior appendages. Mutations in human TBX5 cause Holt-Oram syndrome, a condition characterized by heart and upper limb malformations. Tbx5-knockout mouse embryos have severely impaired forelimb and heart morphogenesis from the earliest stages of their development. However, zebrafish embryos with compromised tbx5 function show a...

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Identifiers

PMID: 24759614
DOI: 10.1098/rsob.140014
PMCID: PMC4043114

Genes

TBX5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Distinct tissue-specific requirements for the zebrafish tbx5 genes during heart, retina and pectoral fin development.PMID 24759614Read ↗

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