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Article

Effects of a non-IGF binding mutant of IGFBP-5 on cell death in human breast cancer cells.

Biochemical and biophysical research communications - 28 Jun 2002

Perks C M, McCaig C, Clarke J B, Clemmons D R, Holly J M P

Abstract excerpt

We have demonstrated previously that IGFBP-5 alone had no effect on cell death but modulated ceramide-induced apoptosis in Hs578T IGF non-responsive cells. To investigate if IGFBP-5 maintains its intrinsic ability to modulate apoptosis in IGF-responsive cells, we used a non-IGF binding mutant of IGFBP-5. In Hs578T cells, non-glycosylated, glycosylated or mutant IGFBP-5 alone each had no effect on cell death,...

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Source

Identifiers

PMID: 12074575
DOI: 10.1016/S0006-291X(02)00570-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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