Article
Rescue of bmp15 deficiency in zebrafish by mutation of inha reveals mechanisms of BMP15 regulation of folliculogenesis.
PLoS genetics - 1 Sept 2023
Zhai Yue, Zhang Xin, Zhao Cheng, Geng Ruijing, Wu Kun, Yuan Mingzhe, Ai Nana, Ge Wei
Abstract excerpt
As an oocyte-specific growth factor, bone morphogenetic protein 15 (BMP15) plays a critical role in controlling folliculogenesis. However, the mechanism of BMP15 action remains elusive. Using zebrafish as the model, we created a bmp15 mutant using CRISPR/Cas9 and demonstrated that bmp15 deficiency caused a significant delay in follicle activation and puberty onset followed by a complete arrest of follicle...
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