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Article

Insulin-like growth factor (IGF) signalling is required for early dorso-anterior development of the zebrafish embryo.

The International journal of developmental biology - 1 Dec 2004

Eivers Edward, McCarthy Karena, Glynn Catherine, Nolan Catherine M, Byrnes Lucy

Abstract excerpt

The insulin-like growth factor (IGF) signalling pathway has been highly conserved in animal evolution and, in mammals and Xenopus, plays a key role in embryonic growth and development, with the IGF-1 receptor (IGF-1R) being a crucial regulator of the signalling cascade. Here we report the first functional role for the IGF pathway in zebrafish. Expression of mRNA coding for a dominant negative IGF-1R resulted in...

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Identifiers

PMID: 15602699
DOI: 10.1387/ijdb.041913ee

Genes

FGF8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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