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Article

IGF-independent effects of insulin-like growth factor binding protein-5 (Igfbp5) in vivo.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Aug 2009

Tripathi Gyanendra, Salih Dervis A M, Drozd Anja C, Cosgrove Ruth A, Cobb Laura J, Pell Jennifer M

Abstract excerpt

IGF activity is regulated tightly by a family of IGF binding proteins (IGFBPs). IGFBP-5 is the most conserved of these and is up-regulated significantly during differentiation of several key lineages and in some cancers. The function of IGFBP-5 in these physiological and pathological situations is unclear, however, several IGFBP-5 sequence motifs and studies in vitro suggest IGF-independent actions. Therefore, we...

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PMID: 19332648
DOI: 10.1096/fj.08-114124

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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