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Article

GDF5 and BMP2 inhibit apoptosis via activation of BMPR2 and subsequent stabilization of XIAP.

Biochimica et biophysica acta - 1 Dec 2009

Liu Zhipei, Shen Jia, Pu Kui, Katus Hugo A, Plöger Frank, Tiefenbacher Christiane P, Chen Xiaobo, Braun Thomas

Abstract excerpt

GDF5 and BMP2, members of the TGF-beta superfamily of growth factors, are known to regulate apoptosis in different cell types either positively or negatively. We wanted to investigate the effects of GDF5 and BMP2 on vascular smooth muscle cells and mouse embryonic fibroblasts and disclose the mec...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19782107
DOI: 10.1016/j.bbamcr.2009.09.012

Genes

BMP2
GDF5
XIAP
BMPR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19782107-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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