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Molecular and functional characterization of two distinct IGF binding protein-6 genes in zebrafish

11 Mar 2009

Abstract excerpt

Insulin-like growth factor binding proteins (IGFBPs) are high-affinity binding partners for IGFs and play important roles in modulating IGF activities. In this study, we have identified and characterized two functional IGFBP-6 genes in zebrafish. Structural, phylogenetic, and comparative genomic analyses indicate that they are co-orthologs of the human IGFBP-6 gene. To gain insight into how the duplicated genes...

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PMID: 19279291
DOI: 10.1152/ajpregu.90969.2008

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