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IGFBP5 regulates fibrocartilage differentiation and cartilage injury induced by T-2 toxin via blocking IGF-1/IGF-1R signalling

11 Feb 2025

Abstract excerpt

OBJECTIVES: Kashin-Beck disease (KBD) is a form of osteoarthropathy that affects the skeletal and joint systems of children and adolescents. Insulin-like growth factor binding protein 5 (IGFBP5) plays an important role in bone growth and development. This study aimed to investigate the role of IGBFP5 in regulating the function and differentiation of chondrocytes in KBD. METHODS: The mRNA and protein expressions...

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PMID: 39932874
DOI: 10.1093/rheumatology/keaf084

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