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<i>Insulin-like growth factor-binding protein 5</i> ( <i>Igfbp5</i> ) compromises survival, growth, muscle development, and fertility in mice

9 Mar 2004

Abstract excerpt

The insulin-like growth factors (IGFs) are essential for development; bioavailable IGF is tightly regulated by six related IGF-binding proteins (IGFBPs). Igfbp5 is the most conserved and is developmentally up-regulated in key lineages and pathologies; in vitro studies suggest that IGFBP-5 functions independently of IGF interaction. Genetic ablation of individual Igfbps has yielded limited phenotypes because of...

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PMID: 15010534
DOI: 10.1073/pnas.0400230101

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