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Article

Ligase-dependent and independent functions of the C-terminus of Mms21 contribute to optimal growth and genome stability in Saccharomyces cerevisiae.

Molecular biology of the cell - 1 Jun 2026

Li Cheung, Vo Anny, Baadi Nkechinye, Thu Yee Mon

Abstract excerpt

An evolutionarily conserved E3 SUMO ligase, Mms21, orchestrates genome integrity processes. Our study examined a mutant of Saccharomyces cerevisiae Mms21, analogous to a mutant identified in a rare human condition characterized by genome instability. The human mutation C-terminally truncated the Mms21 protein, without affecting the residues in the E3 ligase domain. Thus, we hypothesized that the C-terminus...

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Identifiers

PMID: 41949878
DOI: 10.1091/mbc.E25-11-0567
PMCID: PMC13200702

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