Article
Small ubiquitin-related modifier ligase activity of Mms21 is required for maintenance of chromosome integrity during the unperturbed mitotic cell division cycle in Saccharomyces cerevisiae.
The Journal of biological chemistry - 22 Apr 2011
Rai Ragini, Varma Satya P M V, Shinde Nikhil, Ghosh Shilpa, Kumaran Srikala P, Skariah Geena, Laloraya Shikha
Abstract excerpt
The SUMO ligase activity of Mms21/Nse2, a conserved member of the Smc5/6 complex, is required for resisting extrinsically induced genotoxic stress. We report that the Mms21 SUMO ligase activity is also required during the unchallenged mitotic cell cycle in Saccharomyces cerevisiae. SUMO ligase-defective cells were slow growing and spontaneously incurred DNA damage. These cells required caffeine-sensitive Mec1...
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