Article
Schizosaccharomyces pombe Mms1 channels repair of perturbed replication into Rhp51 independent homologous recombination.
DNA repair - 7 Mar 2011
Vejrup-Hansen Rasmus, Mizuno Ken'Ichi, Miyabe Izumi, Fleck Oliver, Holmberg Christian, Murray Johanne M, Carr Antony M, Nielsen Olaf
Abstract excerpt
In both Schizosaccharomyces pombe and Saccharomyces cerevisiae, Mms22 and Mms1 form a complex with important functions in the response to DNA damage, loss of which leads to perturbations during replication. Furthermore, in S. cerevisiae, Mms1 has been suggested to function in concert with a Cullin-like protein, Rtt101/Cul8, a potential paralog of Cullin 4. We performed epistasis analysis between Δmms1 and mutants...
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