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Article

Scc1 sumoylation by Mms21 promotes sister chromatid recombination through counteracting Wapl.

Genes & development - 1 Jul 2012

Wu Nan, Kong Xiangduo, Ji Zhejian, Zeng Weihua, Potts Patrick Ryan, Yokomori Kyoko, Yu Hongtao

Abstract excerpt

DNA double-strand breaks (DSBs) fuel cancer-driving chromosome translocations. Two related structural maintenance of chromosomes (Smc) complexes, cohesin and Smc5/6, promote DSB repair through sister chromatid homologous recombination (SCR). Here we show that the Smc5/6 subunit Mms21 sumoylates multiple lysines of the cohesin subunit Scc1. Mms21 promotes cohesin-dependent small ubiquitin-like modifier (SUMO)...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22751501
DOI: 10.1101/gad.193615.112
PMCID: PMC3403015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Scc1 sumoylation by Mms21 promotes sister chromatid recombination through counteracting Wapl.PMID 22751501Read ↗

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Cohesin promotes the repair of ionizing radiation-induced DNA double-strand breaks in replicated chromatinSemantic proximity Read ↗

Sumoylation and the structural maintenance of chromosomes (Smc) 5/6 complex slow senescence through recombination intermediate resolution.Semantic proximity Read ↗

PolySUMOylation by Siz2 and Mms21 triggers relocation of DNA breaks to nuclear pores through the Slx5/Slx8 STUbL.Semantic proximity Read ↗

Ubc9- and mms21-mediated sumoylation counteracts recombinogenic events at damaged replication forks.Semantic proximity Read ↗

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