Article
Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human disease.
PLoS computational biology - 1 Mar 2018
Baillie J Kenneth, Bretherick Andrew, Haley Christopher S, Clohisey Sara, Gray Alan, Neyton Lucile P A, Barrett Jeffrey, Stahl Eli A, Tenesa Albert, Andersson Robin, Brown J Ben, Faulkner Geoffrey J, Lizio Marina, Schaefer Ulf, Daub Carsten, Itoh Masayoshi, Kondo Naoto, Lassmann Timo, Kawai Jun, Mole Damian, Bajic Vladimir B, Heutink Peter, Rehli Michael, Kawaji Hideya, Sandelin Albin, Suzuki Harukazu, Satsangi Jack, Wells Christine A, Hacohen Nir, Freeman Thomas C, Hayashizaki Yoshihide, Carninci Piero, Forrest Alistair R R, Hume David A
Abstract excerpt
Genetic variants underlying complex traits, including disease susceptibility, are enriched within the transcriptional regulatory elements, promoters and enhancers. There is emerging evidence that regulatory elements associated with particular traits or diseases share similar patterns of transcriptional activity. Accordingly, shared transcriptional activity (coexpression) may help prioritise loci associated with a...
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