Article

The molecular basis, genetic control and pleiotropic effects of local gene co-expression

2020-12-12

Abstract excerpt

Nearby genes are often expressed as a group. Yet, the prevalence, molecular mechanisms and genetic control of local gene co-expression are far from being understood. Here, by leveraging gene expression measurements across 49 human tissues and hundreds of individuals, we found that local gene co-expression occurs in 13% to 53% genes per tissue. By integrating various molecular assays (e.g. ChIP-seq and Hi-C), we es...

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Literature Corpus work: 691307c7-84d7-5d57-be1b-74c4747e99b9
DOI: 10.1101/2020.12.11.421396

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