Article
Population-scale tissue transcriptomics maps long non-coding RNAs to complex disease.
Cell - 13 May 2021
de Goede Olivia M, Nachun Daniel C, Ferraro Nicole M, Gloudemans Michael J, Rao Abhiram S, Smail Craig, Eulalio Tiffany Y, Aguet François, Ng Bernard, Xu Jishu, Barbeira Alvaro N, Castel Stephane E, Kim-Hellmuth Sarah, Park YoSon, Scott Alexandra J, Strober Benjamin J, Brown Christopher D, Wen Xiaoquan, Hall Ira M, Battle Alexis, Lappalainen Tuuli, Im Hae Kyung, Ardlie Kristin G, Mostafavi Sara, Quertermous Thomas, Kirkegaard Karla, Montgomery Stephen B
Abstract excerpt
Long non-coding RNA (lncRNA) genes have well-established and important impacts on molecular and cellular functions. However, among the thousands of lncRNA genes, it is still a major challenge to identify the subset with disease or trait relevance. To systematically characterize these lncRNA genes, we used Genotype Tissue Expression (GTEx) project v8 genetic and multi-tissue transcriptomic data to profile the...
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