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Article

Genetic correlations reveal the shared genetic architecture of transcription in human peripheral blood.

Nature communications - 7 Sept 2017

Lukowski Samuel W, Lloyd-Jones Luke R, Holloway Alexander, Kirsten Holger, Hemani Gibran, Yang Jian, Small Kerrin, Zhao Jing, Metspalu Andres, Dermitzakis Emmanouil T, Gibson Greg, Spector Timothy D, Thiery Joachim, Scholz Markus, Montgomery Grant W, Esko Tonu, Visscher Peter M, Powell Joseph E

Abstract excerpt

Transcript co-expression is regulated by a combination of shared genetic and environmental factors. Here, we estimate the proportion of co-expression that is due to shared genetic variance. To do so, we estimated the genetic correlations between each pairwise combination of 2469 transcripts that are highly heritable and expressed in whole blood in 1748 unrelated individuals of European ancestry. We identify 556...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28883458
DOI: 10.1038/s41467-017-00473-z
PMCID: PMC5589780

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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