Article

Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human disease

2016-12-19

Abstract excerpt

Genetic variants underlying complex traits, including disease susceptibility, are enriched within the transcriptional regulatory elements, promoters and enhancers. There is emerging evidence that regulatory elements associated with particular traits or diseases share patterns of transcriptional regulation. Accordingly, shared transcriptional regulation (coexpression) may help prioritise loci associated with a give...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b3454259-21ce-5b5a-8226-02035bd83e4b
DOI: 10.1101/095349

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human diseaseDOI 10.1101/095349Read

Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human disease.Semantic proximity Read

Discover novel disease-associated genes based on regulatory networks of long-range chromatin interactions.Semantic proximity Read

Long non-coding RNA gene regulation and trait associations across human tissuesSemantic proximity Read

Population-scale tissue transcriptomics maps long non-coding RNAs to complex disease.Semantic proximity Read

Epigenomic regulatory programs reveal the latent heterogeneity of complex diseasesSemantic proximity Read

Identifying Genetic Regulatory Variants that Affect Transcription Factor ActivitySemantic proximity Read

Population-specific genome-wide mapping of expression quantitative trait loci in the colon of Han Chinese.Semantic proximity Read

CATaN maps gene regulatory programs that shape genetic risk across complex diseasesSemantic proximity Read

Disease-associated variants in different categories of disease located in distinct regulatory elements.Semantic proximity Read

Improved detection of genetic effects on promoter usage with augmented transcript annotationsSemantic proximity Read

Combinatorial effects of multiple enhancer variants in linkage disequilibrium dictate levels of gene expression to confer susceptibility to common traits.Semantic proximity Read

Epithelial regulatory networks link non-coding genetic variation to clinical heterogeneity in ulcerative colitisSemantic proximity Read