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Article

Convergent downstream candidate mechanisms of independent intergenic polymorphisms between co-classified diseases implicate epistasis among noncoding elements.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing - 1 Jan 2018

Han Jiali, Li Jianrong, Achour Ikbel, Pesce Lorenzo, Foster Ian, Li Haiquan, Lussier Yves A

Abstract excerpt

Eighty percent of DNA outside protein coding regions was shown biochemically functional by the ENCODE project, enabling studies of their interactions. Studies have since explored how convergent downstream mechanisms arise from independent genetic risks of one complex disease. However, the cross-talk and epistasis between intergenic risks associated with distinct complex diseases have not been comprehensively...

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PMID: 29218911
PMCID: PMC5730078

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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