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Article

Insights into the mechanism of Rad51 recombinase from the structure and properties of a filament interface mutant.

Nucleic acids research - 1 Aug 2010

Chen Jianhong, Villanueva Nicolas, Rould Mark A, Morrical Scott W

Abstract excerpt

Rad51 protein promotes homologous recombination in eukaryotes. Recombination activities are activated by Rad51 filament assembly on ssDNA. Previous studies of yeast Rad51 showed that His352 occupies an important position at the filament interface, where it could relay signals between subunits and active sites. To investigate, we characterized yeast Rad51 H352A and H352Y mutants, and solved the structure of H352Y....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20371520
DOI: 10.1093/nar/gkq209
PMCID: PMC2919713

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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