Article

CRISPR-dependent base editing screens identify separation of function mutants of RADX with altered RAD51 regulatory activity

2023-06-19

Abstract excerpt

RAD51 forms nucleoprotein filaments to promote homologous recombination, replication fork reversal, and fork protection. Numerous factors regulate the stability of these filaments and improper regulation leads to genomic instability and ultimately disease including cancer. RADX is a single stranded DNA binding protein that modulates RAD51 filament stability. Here, we utilize a CRISPR-dependent base editing screen...

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Literature Corpus work: 7d5082e7-b968-5848-b396-8ff14698b7f3
DOI: 10.1101/2023.06.19.545603

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