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Article

Nrf2 activation attenuates genetic endoplasmic reticulum stress induced by a mutation in the phosphomannomutase 2 gene in zebrafish.

Proceedings of the National Academy of Sciences of the United States of America - 13 Mar 2018

Mukaigasa Katsuki, Tsujita Tadayuki, Nguyen Vu Thanh, Li Li, Yagi Hirokazu, Fuse Yuji, Nakajima-Takagi Yaeko, Kato Koichi, Yamamoto Masayuki, Kobayashi Makoto

Abstract excerpt

Nrf2 plays critical roles in animals' defense against electrophiles and oxidative stress by orchestrating the induction of cytoprotective genes. We previously isolated the zebrafish mutant it768, which displays up-regulated expression of Nrf2 target genes in an uninduced state. In this paper, we determine that the gene responsible for it768 was the zebrafish homolog of phosphomannomutase 2 (Pmm2), which is a key...

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Identifiers

PMID: 29472449
DOI: 10.1073/pnas.1714056115
PMCID: PMC5856520

Genes

PMM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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