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Article

Genetic evidence of an evolutionarily conserved role for Nrf2 in the protection against oxidative stress.

Molecular and cellular biology - 1 Nov 2012

Mukaigasa Katsuki, Nguyen Linh T P, Li Li, Nakajima Hitomi, Yamamoto Masayuki, Kobayashi Makoto

Abstract excerpt

Transcription factor Nrf2 is considered a master regulator of antioxidant defense in mammals. However, it is unclear whether this concept is applicable to nonmammalian vertebrates, because no animal model other than Nrf2 knockout mice has been generated to examine the effects of Nrf2 deficiency....

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Identifiers

PMID: 22949501
DOI: 10.1128/MCB.00481-12
PMCID: PMC3486152

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22949501-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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