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Article

Effects of Nrf2 deficiency on arsenic metabolism in mice.

Toxicology and applied pharmacology - 15 Dec 2017

Wang Huihui, Zhu Jiayu, Li Lu, Li Yongfang, Lv Hang, Xu Yuanyuan, Sun Guifan, Pi Jingbo

Abstract excerpt

Inorganic arsenic (iAs) is a known toxicant and carcinogen. Worldwide arsenic exposure has become a threat to human health. The severity of arsenic toxicity is strongly correlated with the speed of arsenic metabolism (methylation) and clearance. Furthermore, oxidative stress is recognized as a major mechanism for arsenic-induced toxicity. Nuclear factor-E2-related factor 2 (Nrf2), a key regulator in cellular...

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Identifiers

PMID: 29108910
DOI: 10.1016/j.taap.2017.11.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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