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Article

Mutations in genes cnc or dKeap1 modulate stress resistance and metabolic processes in Drosophila melanogaster.

Comparative biochemistry and physiology. Part A, Molecular & integrative physiology - 1 Oct 2020

Bayliak Maria M, Demianchuk Oleh I, Gospodaryov Dmytro V, Abrat Oleksandra B, Lylyk Maria P, Storey Kenneth B, Lushchak Volodymyr I

Abstract excerpt

The transcription factor Nrf2 and its negative regulator Keap1 play important roles in the maintenance of redox homeostasis in animal cells. Nrf2 activates defenses against oxidative stress and xenobiotics. Homologs of Nrf2 and Keap1 are present in Drosophila melanogaster (CncC and dKeap1, respectively). The aim of this study was to explore effects of CncC deficiency (due to mutation in the cnc gene) or enhanced...

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Identifiers

PMID: 32579905
DOI: 10.1016/j.cbpa.2020.110746

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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