Article

Establishing an auxin-inducible GFP nanobody-based acute protein knockdown system to mimic hypomorphic mutations during early medaka embryogenesis

2025-05-23

Abstract excerpt

Creating hypomorphic mutations are crucial to study gene function in vivo , especially when null mutations result in (embryonic) lethality. This is especially the case for enzymes involved in glycosylation that, when mutated in human patients, are causing the disease congenital disorders of glycosylation (CDG). To resemble the patient conditions, it would be ideal to acutely modulate the proteins in question to d...

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Literature Corpus work: 1b13e71e-023b-5cd7-afd6-c340744290e3
DOI: 10.1101/2025.05.23.655727

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Establishing an auxin-inducible GFP nanobody-based acute protein knockdown system to mimic hypomorphic mutations during early medaka embryogenesisDOI 10.1101/2025.05.23.655727Read

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