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Article

Keap1 inhibition attenuates glomerulosclerosis.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Apr 2014

Miyazaki Yoichi, Shimizu Akihiro, Pastan Ira, Taguchi Keiko, Naganuma Eriko, Suzuki Takafumi, Hosoya Tatsuo, Yokoo Takashi, Saito Akihiko, Miyata Toshio, Yamamoto Masayuki, Matsusaka Taiji

Abstract excerpt

BACKGROUND: NFE2-related factor 2 (Nrf2) is a master regulatory transcription factor for antioxidant genes. Inhibition of its adaptor protein, Kelch-like ECH-associated protein 1 (Keap1), activates Nrf2. Podocyte injury triggers the progressive deterioration of glomerular damage toward glomerulosclerosis. We examined whether modulation of the Keap1-Nrf2 system has an impact on this process. METHODS: Nrf2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24523358
DOI: 10.1093/ndt/gfu002
PMCID: PMC3967835

Genes

NFE2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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