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Article

Preemptive NUDT15 genotyping: redefining the management of patients with thiopurine-induced toxicity.

Drug metabolism and personalized therapy - 28 Mar 2018

Shah Swarup A V, Paradkar Minal U, Desai Devendra C, Ashavaid Tester F

Abstract excerpt

BACKGROUND: Thiopurine methyltransferase (TPMT) gene variants have achieved limited success in predicting the outcome of thiopurine therapy, which shows wide inter-individual variations. The literature indicates a strong association between the NUDT15 gene variant and thiopurine-induced toxicity in Asian patients. The present study intends to explore the role of the NUDT15 variant (C415T) in Indian patients on...

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Source

Identifiers

PMID: 29470173
DOI: 10.1515/dmpt-2017-0038

Genes

NUDT15
TPMT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Preemptive NUDT15 genotyping: redefining the management of patients with thiopurine-induced toxicity.PMID 29470173Read ↗

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