Article
NUDT15 genotype distributions in the Korean population.
Pharmacogenetics and genomics - 1 May 2017
Kim Hyoung-Tae, Choi Rihwa, Won Hong-Hee, Choe Yon Ho, Kang Ben, Lee Kiwuk, Koo Hong Hoe, Yoo Keon Hee, Kim Young-Ho, Lee Soo-Youn
Abstract excerpt
Thiopurines have a narrow therapeutic range because of frequent toxicity (i.e. marrow suppression), which is only partly explained by TPMT genetic polymorphisms, especially within Asian populations. Recent studies have identified NUDT15 variation as another important factor affecting thiopurine metabolism. In this study, a total of four NUDT15 coding variants (p.Arg139Cys, p.Arg139His, p.Val18Ile, and...
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