Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of NUDT15 c.415C>T allele and thiopurine-induced leukocytopenia in Asians: a systematic review and meta-analysis.

Irish journal of medical science - 1 Feb 2018

Zhang A L, Yang J, Wang H, Lu J L, Tang S, Zhang X J

Abstract excerpt

BACKGROUND: Thiopurines, commonly used to treat autoimmune conditions and cancer, can be limited by life-threatening leucopenia. However, whether NUDT15 (nucleoside diphosphate-linked moiety X-type motif 15) is associated with thiopurine-induced leucopenia in Asians is controversial. METHODS: Relevant studies in English that were published until July 10, 2016 were identified through PubMed, EMbase, and other web...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Asian People
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotype

Share to Leukopenia

Share to Pyrophosphatases

Share to Risk Factors

Source

Identifiers

PMID: 28470355
DOI: 10.1007/s11845-017-1608-x

Genes

NUDT15

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of NUDT15 c.415C>T allele and thiopurine-induced leukocytopenia in Asians: a systematic review and meta-analysis.PMID 28470355Read ↗

A novel single-tube multiplex real-time PCR assay for genotyping of thiopurine intolerance-causing variant NUDT15 c.415C>T.Semantic proximity Read ↗

A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia.Semantic proximity Read ↗

Nucleoside diphosphate-linked moiety X-type motif 15 C415T variant as a predictor for thiopurine-induced toxicity in Indian patients.Semantic proximity Read ↗

Further evidence that a variant of the gene NUDT15 may be an important predictor of azathioprine-induced toxicity in Chinese subjects: a case report.Semantic proximity Read ↗

Combined Detection of NUDT15 Variants Could Highly Predict Thiopurine-induced Leukopenia in Chinese Patients with Inflammatory Bowel Disease: A Multicenter Analysis.Semantic proximity Read ↗

NUDT15 C415T variant compared with TPMT genotyping in predicting azathioprine-induced leucopenia: prospective analysis of 1014 inflammatory bowel disease patients in India.Semantic proximity Read ↗

Preemptive NUDT15 genotyping: redefining the management of patients with thiopurine-induced toxicity.Semantic proximity Read ↗

Implementation of NUDT15 Genotyping to Prevent Azathioprine-Induced Leukopenia for Patients With Autoimmune Disorders in Chinese Population.Semantic proximity Read ↗

Single-Nucleotide Polymorphisms, c.415C > T (Arg139Cys) and c.416G > A (Arg139His), in the NUDT15 Gene Are Associated with Thiopurine-Induced Leukopenia.Semantic proximity Read ↗

NUDT15 p.R139C variant is common and strongly associated with azathioprine-induced early leukopenia and severe alopecia in Korean patients with various neurological diseases.Semantic proximity Read ↗

NUDT15 R139C variation increases the risk of azathioprine-induced toxicity in Chinese subjects: Case report and literature review.Semantic proximity Read ↗

NUDT15 genotype distributions in the Korean population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.