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Article

Nucleoside diphosphate-linked moiety X-type motif 15 C415T variant as a predictor for thiopurine-induced toxicity in Indian patients.

Journal of gastroenterology and hepatology - 1 Mar 2017

Shah Swarup A V, Paradkar Minal, Desai Devendra, Ashavaid Tester F

Abstract excerpt

BACKGROUND AND AIM: Interindividual variation seen in the thiopurine metabolism is attributed to the genetic variant in thiopurine methyltransferase (TPMT) gene leading to myelosuppression. In Asians, the thiopurine-induced toxicity is not completely explained by TPMT variants. Literature indicates that a newer genetic variant in nucleoside diphosphate-linked moiety X-type motif 15 (NUDT15) gene is associated...

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Source

Identifiers

PMID: 27416873
DOI: 10.1111/jgh.13494

Genes

NUDT15
TPMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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Nucleoside diphosphate-linked moiety X-type motif 15 C415T variant as a predictor for thiopurine-induced toxicity in Indian patients.PMID 27416873Read ↗

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