Article
A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia.
Nature genetics - 1 Sept 2014
Yang Suk-Kyun, Hong Myunghee, Baek Jiwon, Choi Hyunchul, Zhao Wanting, Jung Yusun, Haritunians Talin, Ye Byong Duk, Kim Kyung-Jo, Park Sang Hyoung, Park Soo-Kyung, Yang Dong-Hoon, Dubinsky Marla, Lee Inchul, McGovern Dermot P B, Liu Jianjun, Song Kyuyoung
Abstract excerpt
Thiopurine therapy, commonly used in autoimmune conditions, can be complicated by life-threatening leukopenia. This leukopenia is associated with genetic variation in TPMT (encoding thiopurine S-methyltransferase). Despite a lower frequency of TPMT mutations in Asians, the incidence of thiopurine-induced leukopenia is higher in Asians than in individuals of European descent. Here we performed an Immunochip-based...
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