Article
Comparison of variants in TPMT and NUDT15 between sequencing and genotyping methods in a multistate pediatric institution.
Clinical and translational science - 1 Aug 2023
Cook Kelsey J, Grusauskas Victoria, Gloe Lucy, Duong Benjamin Q, Gresh Renee C, Kolb E Anders, Bansal Manisha, Bechtel Allison S, Nagasubramanian Ramamoorthy, Kirwin Susan M, Blake Kathryn V, Seligson Nathan D
Abstract excerpt
The risk of severe adverse events related to thiopurine therapy can be reduced by personalizing dosing based on TPMT and NUDT15 genetic polymorphisms. However, the optimal genetic testing platform has not yet been established. In this study, we report on the TPMT and NUDT15 genotypes and phenotypes generated from 320 patients from a multicenter pediatric healthcare system using both Sanger sequencing and...
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