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Article

A direct sequencing assay for pharmacogenetic testing of thiopurine-intolerant NUDT15 alleles in an Asian population.

BMC research notes - 25 Apr 2022

Poon Kok-Siong, Imran Izz Irfan B, Chew Silvester Kheng-Han, Tan Patrice, Tan Karen Mei-Ling

Abstract excerpt

OBJECTIVE: The nucleoside diphosphate linked moiety X (Nudix)-Type motif 15 (NUDT15) enzyme is involved in thiopurine metabolism. Genetic variants in the NUDT15 gene result in decreased NUDT15 activity, which in addition to decreased thiopurine S-methyltransferase (TPMT) activity, contributes to thiopurine toxicity. Current standard approaches of NUDT15 genetic analysis have mainly been targeting several common...

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Identifiers

PMID: 35468862
DOI: 10.1186/s13104-021-05821-3
PMCID: PMC9036696

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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