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Article

TPMT and NUDT15 genotyping, TPMT enzyme activity and metabolite determination for thiopurines therapy: a reference laboratory experience.

Pharmacogenomics - 1 Jan 2024

Shaaban Sherin, Walker Brandon S, Ji Yuan, Johnson-Davis Kamisha

Abstract excerpt

AIM: To share the experience of a US national reference laboratory, offering genotyping for TPMT and NUDT15, TPMT enzyme phenotyping and detection of thiopurine metabolites. METHODS: Retrospective review of archived datasets related to thiopurines drug therapy including patients' data that underwent TPMT and NUDT15 genotyping, and smaller data sets where genotyping was performed with TPMT enzyme levels...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39957149
DOI: 10.1080/14622416.2025.2463866
PMCID: PMC11901404

Genes

TPMT
NUDT15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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TPMT and NUDT15 genotyping, TPMT enzyme activity and metabolite determination for thiopurines therapy: a reference laboratory experience.PMID 39957149Read ↗

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